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KMID : 1161520190230050355
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Animal Cells and Systems
2019 Volume.23 No. 5 p.355 ~ p.364
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Effects of eicosapentaenoic acid and docosahexaenoic acid on C2C12 cell adipogenesis and inhibition of myotube formation
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Ghnaimawi Saeed
Shelby Sarah
Baum Jamie
Huang Yan
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Abstract
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Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulate cellular metabolic functions and gene expression. This study investigated the impacts of EPA and DHA on gene expression and morphological changes during adipogenic inducement in C2C12 myoblasts. Cells were cultured and treated with differentiation medium with and without 50?μM EPA and DHA. Cells treated with fatty acids had noticeable lipid droplets, but no formation of myotubes compared to control group cells. The expression levels of key genes relevant to adipogenesis and inflammation were significantly higher (P?
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KEYWORD
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n-3 PUFAs, adipogenesis, myoblasts, EPA, DHA
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